Pharmacology course work Essay Example | Topics and Well Written Essays - 250 words

Pharmacology course work - Essay ExampleThe catecholamine theory of mood proposed by Schildkraut suggests that depression is associated with a functional need of noradrenaline at receptor sites within the brain and mania is associated with an excess of noradrenaline at central receptor sites.Recent studies have shown that depressing effectuate on the CNS by ethanol is mediated by gamma aminobutyric acid which is a primary inhibitory neurotransmitter in the CNS. Activation of the GABA receptors by GABA decreases neuronal excitability.Increased stimulation of the NMDA receptor is implicated in the increased free radical production by which it potentiates the toxicity of several peptides and causes neuronal rail at and impairment of synaptic plasticity.MPTP is a model in which the neurotoxin MPTP is employed. This has a competitive advantage over other models as when it causes intoxication it induces a syndrome to the highest degree identical to Parkinsons disease in